منابع مشابه
Airway mucosa: secretory cells, mucus and mucin genes.
The airway mucosa is lined by a continuous epithelium comprised of multiple cell phenotypes, several of which are secretory. Secretions produced by these cells mix with a variety of macromolecules, ions and water to form a respiratory tract fluid that protects the more distal airways and alveoli from injury and infection. The present article highlights the structure of the mucosa, particularly ...
متن کاملDemonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a 'mucus-bicarbonate' barrier.
We examined the ability of the mucus layer adherent to isolated pieces of rabbit gastric mucosa to maintain a pH gradient across it. Using antimony microelectrodes, a stable pH gradient was detected from pH 2.31 +/- 0.04 on the luminal side to pH 7.26 +/- 0.15 (n = 22) on the epithelial side of the mucus layer. The gradient was maintained for at least 60 minutes. A metabolic inhibitor, potassiu...
متن کاملCGRP modulates mucin synthesis in surface mucus cells of rat gastric oxyntic mucosa.
We examined the effects of the calcitonin gene-related peptide (CGRP), including the possible participation of nitric oxide (NO), on mucin biosynthesis in the surface epithelium and remaining deep mucosa as well as the entire mucosa and compared the distribution of CGRP and NO synthase (NOS) using a combination of double immunofluorescence labeling and multiple dye filter. Pieces of tissue obta...
متن کاملAbnormal pattern of mucus-associated M1 antigens in histologically normal mucosa adjacent to colonic adenocarcinomas.
Apparently normal mucosae adjacent to colon adenocarcinomas were studied by cutting strips of mucosa from the entire length of 120 surgical specimens (94 located on the distal colon and 26 on the proximal colon). These mucosae were coiled into "Swiss rolls." Their mucus alterations were mapped by immunoperoxidase using antibodies against M1 antigens, oncofetal markers associated with precancero...
متن کاملMucus glycoproteins from pig gastric mucosa: identification ofdifferent mucin populations from the surface epithelium.
Pig gastric mucins were isolated from the surface epithelium of the cardiac region, corpus and antrum using density-gradient centrifugation after extraction in 6 M guanidinium chloride. In CsCl/0.5 M guanidinium chloride, mucins solubilized from the cardiac region appeared as a broad unimodal band at 1.52 g/ml whereas those from the corpus and antrum occurred as high- and low-density population...
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ژورنال
عنوان ژورنال: Gut
سال: 1985
ISSN: 0017-5749
DOI: 10.1136/gut.26.9.982-b